Order my new cookbook today! 
Disclosure: This post may contain affiliate links. Please see our privacy policy.
Learn how long to bake salmon at 375! Baking salmon at this temperature is an easy way to make a flavorful, flaky, and delicious dinner. This oven-baked salmon recipe features a rich lemon garlic butter sauce, making it moist and irresistible. Plus, you’ll get tips on cooking salmon at 375 in foil and other methods!
How Long Should You Bake Salmon at 375?
The cooking time depends on several factors, including:
➡️ The thickness of the fillets
➡️ The weight of the salmon
➡️ The type of baking dish (glass, metal, etc.)
➡️ Whether it’s wrapped in foil, parchment paper, or left uncovered
🐟 How Long to Bake Salmon at 375
Salmon fillets that are 4 ounces each and ½-inch thick will take 15-20 minutes in an oven preheated to 375F (190C). This time is for salmon in foil packets (or use parchment packets to bake salmon without foil).
Ingredients for oven baked salmon:
- 1 lb fresh salmon (454g; or thawed from frozen)
- 16 thin lemon slices
- 2 tablespoons melted butter
- 2 tablespoons fresh-squeezed lemon juice
- Cajun spice (or other seasonings)
- 8 garlic cloves, minced
- Cooking oil spray
Preheat the oven to 375F (190C). Cut the salmon into four 4-ounce (113g) portions. Cooking smaller pieces ensures even doneness—larger fillets tend to dry out at the edges before the center reaches a safe temperature.
Pat the salmon dry with paper towels. Lightly spray four pieces of foil with cooking spray, then place four lemon slices in the center of each. Set a salmon fillet on top of the lemons. If any piece has a thin edge, tuck it under to prevent overcooking.
Fold up the edges of each foil piece to create a slight barrier for the liquids. Drizzle melted butter over the salmon, then sprinkle with Cajun seasoning (or your favorite herbs and spices).
Add freshly minced garlic and a squeeze of lemon juice to each packet.
Seal the foil packets and arrange them in a single layer on a dark baking sheet. Place the sheet on a rack positioned about one-third down from the top of the oven. Bake for 15-20 minutes.
Once done, check the internal temperature with a meat thermometer. If it hasn’t reached 145F (63C), return it to the oven for a few more minutes.
Important Baked Salmon Tip
Avoid broiling the opened salmon packets after baking—unless you want to risk an oven fire! While some recipes suggest it, I learned the hard way that the butter in my salmon packets caught on fire. (Recipe testing definitely keeps things interesting!)
How to Tell When Salmon is Done
The USDA recommends a minimum internal temperature of 145F (63C) for safely cooked salmon. You’ll know it’s ready when it flakes easily with a fork. To be sure, check the thickest part of the fillet with a kitchen thermometer.
How to Store & Reheat Baked Salmon
Fridge: Store baked salmon in a covered container in the refrigerator for up to 3-4 days, but for the freshest taste, I recommend eating it within 1-2 days.
Freezer: Cooked salmon can be frozen in an airtight bag with the air pressed out.
Reheating: Warm it in the microwave on high for 1-2 minutes—just remember to remove any foil first!
Since these are individual salmon packets, I suggest making just what you’ll eat fresh. Raw salmon can be refrigerated for 1-2 days before cooking or freezing.
How long to bake salmon at 375 (uncovered)?
For uncovered fillets, bake in a preheated oven at 375°F for 10-12 minutes per inch (2.54cm) of thickness. Keep in mind that thicker salmon fillets need more time.
Watch How to Make It!
How Long to Bake Salmon at 375
Ingredients
- 1 lb salmon (454 grams)
- 16 lemon slices (thinly sliced)
- 2 tablespoons melted butter
- 2 tablespoons lemon juice, fresh squeezed
- Cajun spice (or other seasonings)
- 8 cloves garlic, finely chopped
- cooking oil spray of choice
Instructions
- Preheat the oven to 375°F (190°C). Cut the salmon into four 4-ounce (113 gram) pieces.
- Pat the salmon dry with paper towels, and spray 4 pieces of foil with cooking spray. Place 4 lemon slices in the center of each piece of foil.
- Place a piece of salmon on top of the lemons. If the salmon pieces have a very thin edge, you should fold it under. This helps protect them from drying out.
- Fold the edges of each piece of foil up to help contain liquids. Drizzle ½ tablespoon melted butter on top of each salmon piece, and sprinkle on Cajun seasoning (or whatever herbs and spices you’d like). Add fresh minced garlic and ½ tablespoon freshly squeezed lemon juice to each packet.
- Fold the foil packets closed and place them in a single layer on a dark baking sheet. Put the cookie sheet on a rack about ⅓ down from the top of the preheated oven. Bake for 15-20 minutes at 375°F (190°C).
- After baking, check the temperature of the salmon with a meat thermometer. The safe minimum internal temperature for fish is 145°F (63°C). Allow the salmon to rest for 5-10 minutes before serving.
Notes
💭 Expert Tips from Dietitian Summer Yule
This is a level 1 recipe (may help support fat loss). Salmon is a fatty fish, meaning it’s not a lean protein—but that’s a good thing! The fats in salmon are heart-healthy omega-3s, which provide numerous benefits. It’s a fantastic choice for a nutritious main dish that fits into many healthy, weight-loss-friendly meals. If you’re looking to reduce saturated fat, swap the butter in this recipe for olive oil. For those managing high LDL cholesterol, replacing some butter with unsaturated fats is a smart move. Baking salmon makes for an easy, weeknight dinner that’s also low-carb and keto-friendly. To get the most health benefits, leave the skin on—it contains extra omega-3s that you don’t want to waste! Not a fan of Cajun spice? Try dill, parsley, Italian seasoning, lemon pepper, paprika, or other favorite seasonings to make it your own. Nutrition information is for one serving.
nutrition info disclaimer
All recipes on this website may or may not be appropriate for you, depending on your medical needs and personal preferences. Consult with a registered dietitian or your physician if you need help determining the dietary pattern that may be best for you.
The nutrition information is an estimate provided as a courtesy. It will differ depending on the specific brands and ingredients that you use. Calorie information on food labels may be inaccurate, so please don’t sweat the numbers too much.
“To taste” means to your preferences, which may have to be visual to follow food safety rules. Please don’t eat undercooked food x
Nutrition
🥦 What to Serve with Salmon
This easy baked salmon is delicious served with cauliflower rice, white rice, air fryer frozen vegetables, or air fryer frozen green beans. Really, just about any veggie you have laying around plays nicely with salmon.
👨🏾🍳 Other Salmon Recipes
Try these recipes using salmon next:
Join our community! Subscribe for all of the latest and greatest recipes, and follow me on Facebook, Pinterest, Instagram, and YouTube!
Hello! I’m Summer, a registered dietitian and home chef who loves to cook, eat, and create recipes for you! Every recipe on this site has been tested by me to help ensure your success in the kitchen. All eaters are welcome here 🙂